Downloads interactions from the Guide to Pharmacology database

Downloads ligand-receptor interactions from the Guide to Pharmacology (IUPHAR/BPS) database (https://www.guidetopharmacology.org/).

Usage

guide2pharma_download()

Value

A tibble (data frame) of interactions as it is provided by the database

Examples

g2p_data <- guide2pharma_download()
g2p_data
#> # A tibble: 22,867 × 41
#>    target        targe…¹ targe…² targe…³ targe…⁴ targe…⁵ targe…⁶ targe…⁷ targe…⁸
#>    <chr>         <chr>   <chr>   <chr>   <chr>   <chr>   <chr>   <chr>   <chr>  
#>  1 12S-LOX       1387    NA      ALOX12  P18054  ENSG00… NA      NA      NA     
#>  2 15-LOX-1      1388    NA      ALOX15  P16050  ENSG00… NA      NA      NA     
#>  3 15-LOX-1      1388    NA      ALOX15  P16050  ENSG00… NA      NA      NA     
#>  4 15-LOX-1      1388    NA      ALOX15  P16050  ENSG00… NA      NA      NA     
#>  5 15-LOX-1      1388    NA      ALOX15  P16050  ENSG00… NA      NA      NA     
#>  6 15-LOX-2      1389    NA      ALOX15B O15296  ENSG00… NA      NA      NA     
#>  7 15-LOX-2      1389    NA      ALOX15B O15296  ENSG00… NA      NA      NA     
#>  8 3-Mercaptopy… 1446    NA      MPST    P25325  ENSG00… NA      NA      NA     
#>  9 3-phosphoino… 1519    NA      PDPK1   O15530  ENSG00… NA      NA      NA     
#> 10 3-phosphoino… 1519    NA      PDPK1   O15530  ENSG00… NA      NA      NA     
#> # … with 22,857 more rows, 32 more variables: target_ligand_gene_symbol <chr>,
#> #   target_ligand_uniprot_id <chr>, target_ligand_ensembl_gene_id <chr>,
#> #   target_ligand_pubchem_sid <chr>, target_species <chr>, ligand <chr>,
#> #   ligand_id <dbl>, ligand_subunit_ids <chr>, ligand_gene_symbol <chr>,
#> #   ligand_species <chr>, ligand_pubchem_sid <chr>, approved <lgl>, type <chr>,
#> #   action <chr>, action_comment <chr>, selectivity <chr>, endogenous <lgl>,
#> #   primary_target <lgl>, concentration_range <chr>, affinity_units <chr>, …
# # A tibble: 21,586 x 38
#    target target_id target_gene_sym. target_uniprot target_ensembl_.
#    <chr>      <dbl> <chr>            <chr>          <chr>
#  1 12S-L.      1387 ALOX12           P18054         ENSG00000108839
#  2 15-LO.      1388 ALOX15           P16050         ENSG00000161905
#  3 15-LO.      1388 ALOX15           P16050         ENSG00000161905
#  4 15-LO.      1388 ALOX15           P16050         ENSG00000161905
# # . with 21,576 more rows, and 33 more variables: target_ligand <chr>,
# #   target_ligand_id <chr>, target_ligand_gene_symbol <chr>,
# ... (truncated)