PathwayCommons (http://www.pathwaycommons.org/) provides molecular interactions from a number of databases, in either BioPAX or SIF (simple interaction format). This function retrieves all interactions in SIF format. The data is limited to the interacting pair and the type of the interaction.
Examples
pc_interactions <- pathwaycommons_download()
pc_interactions
#> # A tibble: 1,884,849 × 3
#> from type to
#> <chr> <chr> <chr>
#> 1 A1BG controls-expression-of A2M
#> 2 A1BG interacts-with ABCC6
#> 3 A1BG interacts-with ACE2
#> 4 A1BG interacts-with ADAM10
#> 5 A1BG interacts-with ADAM17
#> 6 A1BG interacts-with ADAM9
#> 7 A1BG interacts-with AGO1
#> 8 A1BG controls-phosphorylation-of AKT1
#> 9 A1BG controls-state-change-of AKT1
#> 10 A1BG interacts-with ANXA7
#> # ℹ 1,884,839 more rows
# # A tibble: 1,884,849 x 3
# from type to
# <chr> <chr> <chr>
# 1 A1BG controls-expression-of A2M
# 2 A1BG interacts-with ABCC6
# 3 A1BG interacts-with ACE2
# 4 A1BG interacts-with ADAM10
# 5 A1BG interacts-with ADAM17
# # . with 1,884,839 more rows