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Downloads ligand-receptor interactions from Ramilowski et al. 2015

Source: R/ramilowski.R
ramilowski_download.Rd

Curated ligand-receptor pairs from Supplementary Table 2 of the article "A draft network of ligand-receptor mediated multicellular signaling in human" (https://www.nature.com/articles/ncomms8866).

Usage

ramilowski_download()

Value

A data frame (tibble) with interactions.

Examples

rami_interactions <- ramilowski_download()
rami_interactions
#> # A tibble: 2,557 × 16
#>    Pair.Name    Ligan…¹ Ligan…² Recep…³ Recep…⁴ DLRP  HPMR  IUPHAR HPRD  STRIN…⁵
#>    <chr>        <chr>   <chr>   <chr>   <chr>   <chr> <chr> <chr>  <chr> <chr>  
#>  1 A2M_LRP1     A2M     alpha-… LRP1    low de… NA    HPMR  NA     HPRD  STRING…
#>  2 AANAT_MTNR1A AANAT   aralky… MTNR1A  melato… NA    HPMR  NA     NA    NA     
#>  3 AANAT_MTNR1B AANAT   aralky… MTNR1B  melato… NA    HPMR  NA     NA    NA     
#>  4 ACE_AGTR2    ACE     angiot… AGTR2   angiot… NA    NA    NA     HPRD  NA     
#>  5 ACE_BDKRB2   ACE     angiot… BDKRB2  bradyk… NA    NA    NA     HPRD  NA     
#>  6 ADAM10_AXL   ADAM10  ADAM m… AXL     AXL re… NA    NA    NA     HPRD  NA     
#>  7 ADAM10_EPHA3 ADAM10  ADAM m… EPHA3   EPH re… NA    NA    NA     HPRD  NA     
#>  8 ADAM12_ITGA9 ADAM12  ADAM m… ITGA9   integr… NA    HPMR  NA     NA    STRING…
#>  9 ADAM12_ITGB1 ADAM12  ADAM m… ITGB1   integr… NA    HPMR  NA     NA    STRING…
#> 10 ADAM12_SDC4  ADAM12  ADAM m… SDC4    syndec… NA    HPMR  NA     NA    STRING…
#> # … with 2,547 more rows, 6 more variables: STRING.experiment <chr>,
#> #   HPMR.Ligand <chr>, HPMR.Receptor <chr>, PMID.Manual <chr>,
#> #   Pair.Source <chr>, Pair.Evidence <chr>, and abbreviated variable names
#> #   ¹​Ligand.ApprovedSymbol, ²​Ligand.Name, ³​Receptor.ApprovedSymbol,
#> #   ⁴​Receptor.Name, ⁵​STRING.binding
# # A tibble: 2,557 x 16
#    Pair.Name Ligand.Approved. Ligand.Name Receptor.Approv.
#    <chr>     <chr>            <chr>       <chr>
#  1 A2M_LRP1  A2M              alpha-2-ma. LRP1
#  2 AANAT_MT. AANAT            aralkylami. MTNR1A
#  3 AANAT_MT. AANAT            aralkylami. MTNR1B
#  4 ACE_AGTR2 ACE              angiotensi. AGTR2
#  5 ACE_BDKR. ACE              angiotensi. BDKRB2
# # . with 2,547 more rows, and 12 more variables: Receptor.Name <chr>,
# #   DLRP <chr>, HPMR <chr>, IUPHAR <chr>, HPRD <chr>,
# #   STRING.binding <chr>, STRING.experiment <chr>, HPMR.Ligand <chr>,
# #   HPMR.Receptor <chr>, PMID.Manual <chr>, Pair.Source <chr>,
# #   Pair.Evidence <chr>