Downloads ligand-receptor interactions from Ramilowski et al. 2015
Source:R/ramilowski.R
ramilowski_download.RdCurated ligand-receptor pairs from Supplementary Table 2 of the article "A draft network of ligand-receptor mediated multicellular signaling in human" (https://www.nature.com/articles/ncomms8866).
Examples
rami_interactions <- ramilowski_download()
rami_interactions
#> # A tibble: 2,557 × 16
#> Pair.Name Ligand.ApprovedSymbol Ligand.Name Receptor.ApprovedSym…¹
#> <chr> <chr> <chr> <chr>
#> 1 A2M_LRP1 A2M alpha-2-macroglobu… LRP1
#> 2 AANAT_MTNR1A AANAT aralkylamine N-ace… MTNR1A
#> 3 AANAT_MTNR1B AANAT aralkylamine N-ace… MTNR1B
#> 4 ACE_AGTR2 ACE angiotensin I conv… AGTR2
#> 5 ACE_BDKRB2 ACE angiotensin I conv… BDKRB2
#> 6 ADAM10_AXL ADAM10 ADAM metallopeptid… AXL
#> 7 ADAM10_EPHA3 ADAM10 ADAM metallopeptid… EPHA3
#> 8 ADAM12_ITGA9 ADAM12 ADAM metallopeptid… ITGA9
#> 9 ADAM12_ITGB1 ADAM12 ADAM metallopeptid… ITGB1
#> 10 ADAM12_SDC4 ADAM12 ADAM metallopeptid… SDC4
#> # ℹ 2,547 more rows
#> # ℹ abbreviated name: ¹Receptor.ApprovedSymbol
#> # ℹ 12 more variables: Receptor.Name <chr>, DLRP <chr>, HPMR <chr>,
#> # IUPHAR <chr>, HPRD <chr>, STRING.binding <chr>, STRING.experiment <chr>,
#> # HPMR.Ligand <chr>, HPMR.Receptor <chr>, PMID.Manual <chr>,
#> # Pair.Source <chr>, Pair.Evidence <chr>
# # A tibble: 2,557 x 16
# Pair.Name Ligand.Approved. Ligand.Name Receptor.Approv.
# <chr> <chr> <chr> <chr>
# 1 A2M_LRP1 A2M alpha-2-ma. LRP1
# 2 AANAT_MT. AANAT aralkylami. MTNR1A
# 3 AANAT_MT. AANAT aralkylami. MTNR1B
# 4 ACE_AGTR2 ACE angiotensi. AGTR2
# 5 ACE_BDKR. ACE angiotensi. BDKRB2
# # . with 2,547 more rows, and 12 more variables: Receptor.Name <chr>,
# # DLRP <chr>, HPMR <chr>, IUPHAR <chr>, HPRD <chr>,
# # STRING.binding <chr>, STRING.experiment <chr>, HPMR.Ligand <chr>,
# # HPMR.Receptor <chr>, PMID.Manual <chr>, Pair.Source <chr>,
# # Pair.Evidence <chr>