Downloads transcriptional and post-transcriptional regulatory interactions
from the RegNetwork database (http://www.regnetworkweb.org/). The
information about effect signs (stimulation or inhibition), provided by
regnetwork_directions are included in the result.
Examples
regn_interactions <- regnetwork_download()
regn_interactions
#> # A tibble: 372,778 × 7
#> source_genesymbol source_entrez target_genesymbol target_entrez effect
#> <chr> <chr> <chr> <chr> <dbl>
#> 1 USF1 7391 S100A6 6277 NA
#> 2 USF1 7391 DUSP1 1843 NA
#> 3 USF1 7391 C4A 720 NA
#> 4 USF1 7391 ABCA1 19 NA
#> 5 TP53 7157 TP73 7161 1
#> 6 TP53 7157 SIAH1 6477 1
#> 7 TP53 7157 PMAIP1 5366 1
#> 8 TP53 7157 EI24 9538 1
#> 9 TP53 7157 CDKN1A 1026 1
#> 10 TP53 7157 CCNG1 900 1
#> # ℹ 372,768 more rows
#> # ℹ 2 more variables: source_type <chr>, target_type <chr>
# # A tibble: 372,778 x 7
# source_genesymb. source_entrez target_genesymb. target_entrez
# <chr> <chr> <chr> <chr>
# 1 USF1 7391 S100A6 6277
# 2 USF1 7391 DUSP1 1843
# 3 USF1 7391 C4A 720
# 4 USF1 7391 ABCA1 19
# 5 TP53 7157 TP73 7161
# # . with 372,768 more rows, and 3 more variables: effect <dbl>,
# # source_type <chr>, target_type <chr>