ReMap (http://remap.univ-amu.fr/) is a database of ChIP-Seq experiments. It provides raw and merged peaks and CRMs (cis regulatory motifs) with their associations to regulators (TFs). TF-target relationships can be derived as it is written in Garcia-Alonso et al. 2019: "For ChIP-seq, we downloaded the binding peaks from ReMap and scored the interactions between each TF and each gene according to the distance between the TFBSs and the genes’ transcription start sites. We evaluated different filtering strategies that consisted of selecting only the top-scoring 100, 200, 500, and 1000 target genes for each TF." (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673718/#s1title). This function returns the top TF-target relationships as used in DoRothEA: https://github.com/saezlab/dorothea/blob/master/inst/scripts/02_chip_seq.R).
Examples
remap_interactions <- remap_dorothea_download()
remap_interactions
#> # A tibble: 136,988 × 2
#> tf target
#> <chr> <chr>
#> 1 ADNP ABCC1
#> 2 ADNP ABCC6
#> 3 ADNP ABHD5
#> 4 ADNP ABT1
#> 5 ADNP AC002066.1
#> 6 ADNP AC002127.4
#> 7 ADNP AC005514.2
#> 8 ADNP AC006076.1
#> 9 ADNP AC006552.1
#> 10 ADNP AC007319.1
#> # ℹ 136,978 more rows
# # A tibble: 136,988 x 2
# tf target
# <chr> <chr>
# 1 ADNP ABCC1
# 2 ADNP ABCC6
# 3 ADNP ABHD5
# 4 ADNP ABT1
# 5 ADNP AC002066.1
# # . with 136,978 more rows