ReMap (http://remap.univ-amu.fr/) is a database of ChIP-Seq experiments. It provides raw and merged peaks and CRMs (cis regulatory motifs) with their associations to regulators (TFs). TF-target relationships can be derived as it is written in Garcia-Alonso et al. 2019: "For ChIP-seq, we downloaded the binding peaks from ReMap and scored the interactions between each TF and each gene according to the distance between the TFBSs and the genes’ transcription start sites. We evaluated different filtering strategies that consisted of selecting only the top-scoring 100, 200, 500, and 1000 target genes for each TF." (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673718/#s1title). This function retrieves the full processed TF-target list from the data deposited in https://zenodo.org/record/3713238.
Examples
if (FALSE) {
remap_interactions <- remap_tf_target_download()
remap_interactions
# # A tibble: 9,546,470 x 4
# source_genesymbol target_genesymbol target_ensembl score
# <chr> <chr> <chr> <dbl>
# 1 ADNP PTPRS ENSG00000105426.16 1000
# 2 AFF4 PRKCH ENSG00000027075.14 1000
# 3 AHR CTNND2 ENSG00000169862.18 1000
# 4 AR PDE4D ENSG00000113448.18 1000
# 5 ARID1A PLEC ENSG00000178209.14 1000
# # . with 9,546,460 more rows
}