Downloads the ReMap TF-target interactions as processed by Garcia-Alonso et al. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673718/#s1title) and filters them based on a score threshold, the top targets and whether the TF is included in the TF census (Vaquerizas et al. 2009). The code for filtering is adapted from DoRothEA, written by Christian Holland.

## Usage

remap_filtered(score = 100, top_targets = 500, only_known_tfs = TRUE)

## Arguments

score

Numeric: a minimum score between 0 and 1000, records with lower scores will be excluded. If NULL no filtering performed.

top_targets

Numeric: the number of top scoring targets for each TF. Essentially the maximum number of targets per TF. If NULL the number of targets is not restricted.

only_known_tfs

Logical: whether to exclude TFs which are not in TF census.

## Value

Data frame with TF-target relationships.

• remap_tf_target_download

• remap_filtered

• tfcensus_download

## Examples

if (FALSE) {
remap_interactions <- remap_filtered()
nrow(remap_interactions)
# [1] 145680

remap_interactions <- remap_filtered(top_targets = 100)
remap_interactions
# # A tibble: 30,330 x 2
#    source_genesymbol target_genesymbol
#    <chr>             <chr>